Cytotoxic strains of Pseudomonas aeruginosa can damage the intact corneal surface in vitro.

@article{Fleiszig1998CytotoxicSO,
  title={Cytotoxic strains of Pseudomonas aeruginosa can damage the intact corneal surface in vitro.},
  author={Suzanne M. J. Fleiszig and Ellen J. Lee and Chris Yuzheng Wu and Renisa C. Andika and Vicky Vallas and Marta Portoles and Dara W. Frank},
  journal={The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc},
  year={1998},
  volume={24 1},
  pages={
          41-7
        }
}
PURPOSE Although the corneal epithelial cell layer is believed to serve as a barrier against most types of bacteria, certain strains of P. aeruginosa have been shown to kill corneal epithelial cells in primary cultures. The aim of this study was to test whether these strains could damage epithelia on uninjured whole corneas. METHODS Five-week-old Sprague-Dawley rats were sacrificed and their eyes were placed in organ culture. The corneal surface of each eye was incubated with 8 microL of… CONTINUE READING

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