Cytotoxic steroids of Gelsemium sempervirens.

  title={Cytotoxic steroids of Gelsemium sempervirens.},
  author={Y Schun and Geoffrey A. Cordell},
  journal={Journal of natural products},
  volume={50 2},
A new pregnane derivative, 12 beta-hydroxy-5 alpha-pregn-16-ene-3,20-dione, along with the known derivative 12 beta-hydroxy-pregna-4,16-diene-3,20-dione have been isolated from a MeOH extract of the stem of Gelsemium sempervirens and found to be the principal cytotoxic entities. The 13C-nmr spectra of both compounds were assigned by comparison with other pregnane analogs thereby allowing confirmation of the stereochemistry at C-5 in compound. Heteronuclear 2D correlation and selective INEPT… CONTINUE READING