Cytotoxic staurosporines from the marine ascidian Cystodytes solitus.

@article{Reyes2008CytotoxicSF,
  title={Cytotoxic staurosporines from the marine ascidian Cystodytes solitus.},
  author={Fernando Reyes and Rogelio Fernández and Alfredo Ca{\~n}ada Rodr{\'i}guez and Santiago Bueno and Carlos de Eguilior and Andr{\'e}s M Francesch and Carmen Cuevas},
  journal={Journal of natural products},
  year={2008},
  volume={71 6},
  pages={
          1046-8
        }
}
Two new indolocarbazole alkaloids, 7-oxo-3,8,9-trihydroxystaurosporine (1) and 7-oxo-8,9-dihydroxy-4'-N-demethylstaurosporine (2), were isolated from samples of the marine ascidian Cystodytes solitus. Their structures were determined by a combination of spectroscopic techniques, including (+)-HRMALDITOFMS and 1D and 2D NMR spectroscopy, and comparison with published data for related structures. Both compounds displayed strong cytotoxicity against three human tumor cell lines. 
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