Cytotoxic staurosporines from the marine ascidian Cystodytes solitus.

  title={Cytotoxic staurosporines from the marine ascidian Cystodytes solitus.},
  author={Fernando Reyes and Rogelio Fernández and Alfredo Ca{\~n}ada Rodr{\'i}guez and Santiago Bueno and Carlos de Eguilior and Andr{\'e}s M Francesch and Carmen Cuevas},
  journal={Journal of natural products},
  volume={71 6},
Two new indolocarbazole alkaloids, 7-oxo-3,8,9-trihydroxystaurosporine (1) and 7-oxo-8,9-dihydroxy-4'-N-demethylstaurosporine (2), were isolated from samples of the marine ascidian Cystodytes solitus. Their structures were determined by a combination of spectroscopic techniques, including (+)-HRMALDITOFMS and 1D and 2D NMR spectroscopy, and comparison with published data for related structures. Both compounds displayed strong cytotoxicity against three human tumor cell lines. 
Streptomycindole, an Indole Alkaloid from a Marine Streptomyces sp. DA22 Associated with South China Sea Sponge Craniella australiensis
A new indole alkaloid, streptomycindole (1), and a known related compound, N-phenylacetyl-L-tryptophan (2), have been isolated from Streptomyces sp. DA22, associated with South China Sea spongeExpand
Alkaloids from Marine Ascidians
About 300 alkaloid structures isolated from marine ascidians are discussed in term of their occurrence, structural type and reported pharmacological activity, highlighting their potential as therapeutic agents for the treatment of cancer or viral infections. Expand
Marine Natural Product Bis-indole Alkaloid Caulerpin: Chemistry and Biology.
The discovery and isolation of caulerpin, and its potential medicinal and chemical applications in chronological order with various aspects are summarized. Expand
Indolo[2,3-a]carbazoles: diversity, biological properties, application in antitumor therapy
This review presents the history of the discovery of indolo[2,3-a]carbazoles, lists the currently known natural compounds of this subclass, and gives the sources for their isolation. The mainExpand
The Chemistry of Marine Tunicates
The chapter illustrates the chemistry which has been generated through the investigation of marine ascidians in the last 30 years, highlighting the structural diversity of the compounds produced byExpand
Chemistry and Properties of Indolocarbazoles.
This review aims at providing a broad survey of the chemistry and properties of indolocarbazoles from an interdisciplinary point of view, with particular emphasis on practical synthetic aspects, as well as certain topics which have not been previously accounted for in detail. Expand
Ascidians (Tunicates)–1
The article contains sections titled: Reminder About the Concept of the Chordata1 Description of Tunicates and Classification of the Ascidiacea General Information on the Chemistry ofExpand
Marine Indole Alkaloids
Several marine-derived indoles were found to possess cytotoxic, antineoplastic, antibacterial and antimicrobial activities, in addition to the action on human enzymes and receptors. Expand
Streptomyces sp. BV410 isolate from chamomile rhizosphere soil efficiently produces staurosporine with antifungal and antiangiogenic properties
A new, efficient producing strain of commercially significant staurosporine has been described along with optimized fermentation conditions, which may lead to optimization of the stauosporine scaffold and its wider applicability. Expand
Analysis of alkaloids (indole alkaloids, isoquinoline alkaloids, tropane alkaloids)
Abstract Alkaloids are a large cluster of molecules found in Mother Nature all over the world. They are all secondary compounds and collection of miscellaneous elements and biomolecules, derivedExpand


Carbon-13 NMR Spectroscopy: High-Resolution Methods and Applications in Organic Chemistry and Biochemistry
Introduction to NMR Spectroscopy Instrumental Methods of 13C NMR Spectroscopy 13C NMR Spectral Parameters and Structural Properties 13C NMR Spectroscopy of Organic Compounds 13C NMR Spectra ofExpand