Cytotoxic saponins from Schefflera fagueti.

  title={Cytotoxic saponins from Schefflera fagueti.},
  author={Giuseppina Cioffi and Alessandra Braca and Giuseppina Autore and Ivano Morelli and Aldo Pinto and Fabio Venturella and Nunziatina De Tommasi},
  journal={Planta medica},
  volume={69 8},
Six new lupane (1 - 4) and oleanane saponins (5 and 6) were isolated from the aerial parts of Schefflera fagueti Baill. (Araliaceae). Their structures were determined by 2D-NMR spectroscopy (DQF-COSY, 1D-TOCSY, 2D-HOHAHA, 1D-ROESY, HSQC, HMBC). The antiproliferative activity of compounds 1 - 6 and of their prosapogenins (1a - 6a) was evaluated using three continuous murine and human culture cell lines J774, HEK-293, WEHI-164. Oleanane saponins 5 and 6 were the most active, showing significant… CONTINUE READING