Cytotoxic ribonucleases: molecular weapons and their targets.

  title={Cytotoxic ribonucleases: molecular weapons and their targets.},
  author={Alexander A. Makarov and Olga N. Ilinskaya},
  journal={FEBS letters},
  volume={540 1-3},
Many ribonucleases (RNases) are highly cytotoxic. In some cases, they attack selectively malignant cells, triggering apoptotic response, and therefore are considered as alternative chemotherapeutic drugs. Factors that determine the cytotoxicity of RNases, primarily of those of microbial origin, are reviewed here. These factors include catalytic activity, ability to escape natural inhibitors, stability, and efficiency of internalization. The latter is, in turn, determined by positive charge on… CONTINUE READING

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