Cytotoxic prenylflavanones from Taiwanese propolis.

  title={Cytotoxic prenylflavanones from Taiwanese propolis.},
  author={C E Chen and C L Wu and Horng-Shing Shy and Jen-kun Lin},
  journal={Journal of natural products},
  volume={66 4},
Two new prenylflavanones, propolin A (2) and propolin B (3), were isolated and characterized from Taiwanese propolis. Both compounds were found to have cytotoxic properties against three cancer cell lines. DNA content analyses and DNA fragmentation indicated that propolin A (2) efficiently induced apoptosis in cancer cell lines, but had no effect on the cell cycle program. Furthermore, both propolin A (2) and B (3) are potential antioxidant agents and show strong scavenging effects against most… CONTINUE READING

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