Cytotoxic natural antibodies against human tumours: an option for anti-cancer immunotherapy?

Abstract

Healthy individuals may contain in their peripheral blood antibodies which are able to destroy human tumour cells mediated either by complement-dependent cytotoxicity or by apoptosis. The largest proportion of these antibodies is of IgM isotype and directed against distinct tumour associated carbohydrate epitopes. Although the origin of these antibodies is… (More)
DOI: 10.1016/j.autrev.2008.03.012

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