Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense.

  title={Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense.},
  author={A. Aly and R. Edrada-Ebel and Ine Dewi Indriani and V. Wray and W. M{\"u}ller and F. Totzke and U. Zirrgiebel and C. Sch{\"a}chtele and M. Kubbutat and W. H. Lin and P. Proksch and R. Ebel},
  journal={Journal of natural products},
  volume={71 6},
From the Egyptian medicinal plant Polygonum senegalense the fungal endophyte Alternaria sp. was isolated. Extracts of the fungus grown either in liquid culture or on solid rice media exhibited cytotoxic activity when tested in vitro against L5178Y cells. Chromatographic separation of the extracts yielded 15 natural products, out of which seven were new compounds, with both fungal extracts differing considerably with regard to their secondary metabolites. Compounds 1, 2, 3, 6, and 7 showed… Expand
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