Cytotoxic lymphocytes; instigators of dramatic target cell death.

  title={Cytotoxic lymphocytes; instigators of dramatic target cell death.},
  author={Nigel J. Waterhouse and Chris J P Clarke and Karin A. Sedelies and Michele W L Teng and Joseph A. Trapani},
  journal={Biochemical pharmacology},
  volume={68 6},
Most mammalian cells are constantly threatened by viral infection and oncogenic transformation. To maintain healthy function of organs and tissues it is critical that afflicted cells are efficiently detected and removed. Cytotoxic lymphocytes (CL) are chiefly responsible for efficiently seeking out and eliminating damaged or infected cells. It is known that CLs must specifically recognize and bind to their targets, but the molecular events that occur within the target cell that lead to its… CONTINUE READING

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