Cytotoxic lesions of the hippocampus increase social investigation but do not impair social-recognition memory

  title={Cytotoxic lesions of the hippocampus increase social investigation but do not impair social-recognition memory},
  author={D. Bannerman and M. Lemaire and S. Beggs and J. Rawlins and S. Iversen},
  journal={Experimental Brain Research},
  • D. Bannerman, M. Lemaire, +2 authors S. Iversen
  • Published 2001
  • Medicine, Psychology
  • Experimental Brain Research
  • Abstract. A number of studies have implicated the hippocampal formation in social-recognition memory in the rat. The present study addressed this issue directly by assessing the effects of cytotoxic lesions confined to the hippocampus proper, encompassing the four CA subfields and the dentate gyrus, on this behavioural task. Ibotenate-induced hippocampal lesions led to locomotor hyperactivity and a marked spatial working-memory impairment on the elevated T-maze. In addition, they also led to… CONTINUE READING
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