Cytotoxic iridoids from the roots of Patrinia scabra.


Six new iridoid glucosides, patriridosides D-I (1-6), and one new iridoid, scabrol A (7), along with 12 known non-glycosidic and glycosidic iridoids (8-19), have been isolated from an ethanolic extract of the roots of Patrinia scabra. The cytotoxic activity of the isolated compounds against human cervical carcinoma HeLa cells and gastric carcinoma MNK-45 cells was evaluated using the MTT assay. Compounds 1, 4-6, 8, and 18 showed cytotoxic activities against the MNK-45 cell line with respective IC₅₀ values of 15.6, 8.7, 9.4, 30.9, 23.8, and 11.2 μM, while only compound 10 showed cytotoxicity against the HeLa cell line, with an IC₅₀ value of 24.5 μM.

DOI: 10.1021/np300286t

Cite this paper

@article{Li2012CytotoxicIF, title={Cytotoxic iridoids from the roots of Patrinia scabra.}, author={Ning Li and Lei Di and Wen-chao Gao and Kai-jin Wang and Ling-Bo Zu}, journal={Journal of natural products}, year={2012}, volume={75 10}, pages={1723-8} }