Cytotoxic indole alkaloids from Tabernaemontana divaricata.

  title={Cytotoxic indole alkaloids from Tabernaemontana divaricata.},
  author={Weimin Bao and Ju-Ming Yan and Gui-Guang Cheng and Xing-yao Li and Ya-Ping Liu and Yan Li and Xiang-Hai Cai and Xiao-Dong Luo},
  journal={Journal of natural products},
  volume={76 8},
Five new vobasinyl-ibogan-type bisindole alkaloids, tabernaricatines A-E (1-5), two new monomers, tabernaricatines F and G (6 and 7), and 24 known indole alkaloids were isolated from the aerial parts of Tabernaemontana divaricata. Alkaloids 1 and 2 are the first vobasinyl-ibogan-type alkaloids possessing a six-membered ring via an ether linkage between C-17 and C-21. All compounds except for 3 were evaluated for their cytotoxicity against five human cancer cell lines; conophylline showed… CONTINUE READING