Cytotoxic granule-mediated apoptosis: unraveling the complex mechanism.

  title={Cytotoxic granule-mediated apoptosis: unraveling the complex mechanism.},
  author={S. K. Muruga Raja and Sunil S. Metkar and Christopher J. Froelich},
  journal={Current opinion in immunology},
  volume={15 5},
The molecular details of cytotoxic granule-mediated apoptosis have been gleaned from the study of the effects of isolated granzymes and perforin on target cells. Recent evidence indicates that the physiological apoptosis-inducing form is a multi-component macro-complex consisting of cationic granule proteins non-covalently linked to the chondroitin-sulfate proteoglycan, serglycin. 

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