Cytotoxic gammadelta or alphabeta T cells with a natural killer cell marker, CD56, induced from human peripheral blood lymphocytes by a combination of IL-12 and IL-2.

@article{Satoh1996CytotoxicGO,
  title={Cytotoxic gammadelta or alphabeta T cells with a natural killer cell marker, CD56, induced from human peripheral blood lymphocytes by a combination of IL-12 and IL-2.},
  author={Masahiko Satoh and Shuhji Seki and Wataru Hashimoto and Kazumasa Ogasawara and Takashi Kobayashi and Kotaro Kumagai and Seiki Matsuno and Kazuyoshi Takeda},
  journal={Journal of immunology},
  year={1996},
  volume={157 9},
  pages={3886-92}
}
Populations of cytotoxic CD3+CD56+ cells were selectively expanded when monocyte-depleted human PBL (M(-) PBL) were cultured with 20 U/ml IL-12 and 100 U/ml IL-2. In a majority of cases, CD4-CD8- as well as CD8+ gammadelta T cells with CD56 Ag were induced, but in some cases CD4+CD56+ alphabeta T cells were selectively increased. Determination of which will increase, gammadelta or alphabeta T cells, apparently is dependent upon individuals. When M(-) PBL were stimulated with IL-12 and IL-2 in… CONTINUE READING

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