Cytotoxic fatty acid from Pleurocybella porrigens.

  title={Cytotoxic fatty acid from Pleurocybella porrigens.},
  author={Tatsuya Hasegawa and Mayumi Ishibashi and Takanobu Takata and F. Takano and Tomihisa Ohta},
  journal={Chemical & pharmaceutical bulletin},
  volume={55 12},
The new conjugated ketonic fatty acid, porrigenic acid (1), was isolated as a cytotoxic constituent of Pleurocybella porrigens. The structure of 1 was elucidated using spectroscopic methods including 1D and 2D NMR and MS. The absolute stereochemistry of 1 was determined by application of the exciton chirality method. Compound 1 exhibited cytotoxic activity against myeloma THP-1 cells, but did not show any significant toxicity against B16F1 melanoma. This is the first report of the isolation and… CONTINUE READING