Cytotoxic effects of sesquiterpene lactones from the flowers of Hemisteptia lyrata B.

@article{Ha2003CytotoxicEO,
  title={Cytotoxic effects of sesquiterpene lactones from the flowers of Hemisteptia lyrata B.},
  author={Tae Joung Ha and Dae Sik Jang and Jong Rok Lee and Kyung Dong Lee and Jun Kyong Lee and Seon Woo Hwang and Hwa Jin Jung and Sang Hae Nam and Ki Hun Park and Min Yang},
  journal={Archives of pharmacal research},
  year={2003},
  volume={26 11},
  pages={925-8}
}
Four guaia-12,6-olide type sesquiterpene lactones, aguerin B (1), 8alpha-acetoxyzaluzanin C (2), cynaropicrin (3), and deacylcynaropicrin (4), were isolated from the flowers of Hemisteptia lyrata Bunge. It is the first report on the isolation of compounds 1-4 from Hemisteptia species. All the isolates (1-4) were examined for their cytotoxic activity against SK-OV-3, LOX-IMVI, A549, MCF-7, PC-3, and HCT-15 human cancer cell lines.