Cytotoxic effects of sesquiterpene lactones from the flowers ofHemisteptia lyrata B

  title={Cytotoxic effects of sesquiterpene lactones from the flowers ofHemisteptia lyrata B},
  author={T. Ha and D. Jang and J. R. Lee and K. Lee and Jun Lee and S. Hwang and H. Jung and S. Nam and K. Park and M. Yang},
  journal={Archives of Pharmacal Research},
  • T. Ha, D. Jang, +7 authors M. Yang
  • Published 2003
  • Chemistry, Medicine
  • Archives of Pharmacal Research
  • Four guaia-12,6-olide type sesquiterpene lactones, aguerin B (1), 8α-acetoxyzaluzanin C (2), cynaropicrin (3), and deacylcynaropicrin (4), were isolated from the flowers ofHemisteptia lyrata Bunge. It is the first report on the isolation of compounds1-4 from Hemisteptia species. All the isolates (1-4) were examined for their cytotoxic activity against SK-OV-3, LOX-IMVI, A549, MCF-7, PC-3, and HCT-15 human cancer cell lines. 
    27 Citations
    Cytotoxic sesquiterpene lactones fromSaussurea calcicola
    • 24
    • PDF
    Synthesis of cynaropicrin-d(4).
    • 7
    Antitrypanosomal structure-activity-relationship study of synthetic cynaropicrin derivatives.
    • 13
    Cynaropicrin and inhibition of NF-κB activation: A structure activity relationship study.
    Antiproliferative Effects of Cynara cardunculus L. var. altilis (DC) Lipophilic Extracts
    • 21
    • PDF


    Hemistepsins with cytotoxic activity from Hemisteptia lyrata.
    • 11
    Sesquiterpene lactones of Conocephalum conicum
    • 36
    Two sesquiterpene lactones from Centaurea canariensis
    • 35
    • Highly Influential
    Sesquiterpene antitumor agents: inhibitors of cellular metabolism.
    • 169