Cytotoxic effects of replication-competent adenoviruses on human esophageal carcinoma are enhanced by forced p53 expression

Abstract

Improvement of transduction and augmentation of cytotoxicity are crucial for adenoviruses (Ad)-mediated gene therapy for cancer. Down-regulated expression of type 5 Ad (Ad5) receptors on human tumors hampered Ad-mediated transduction. Furthermore, a role of the p53 pathways in cytotoxicity mediated by replication-competent Ad remained uncharacterized. We… (More)
DOI: 10.1186/s12885-015-1482-8

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@inproceedings{Yang2015CytotoxicEO, title={Cytotoxic effects of replication-competent adenoviruses on human esophageal carcinoma are enhanced by forced p53 expression}, author={Shan Yang and Kiyoko Kawamura and Shinya Okamoto and Suguru Yamauchi and Masato Shingyoji and Ikuo Sekine and Hiroshi Kobayashi and Yuji Tada and Koichiro Tatsumi and Kenzo Hiroshima and Hideaki Shimada and Masatoshi Tagawa}, booktitle={BMC Cancer}, year={2015} }