Cytotoxic effects of iron oxide nanoparticles and implications for safety in cell labelling.

@article{Soenen2011CytotoxicEO,
  title={Cytotoxic effects of iron oxide nanoparticles and implications for safety in cell labelling.},
  author={Stefaan J Soenen and Uwe Himmelreich and Nele R Nuytten and Marcel De Cuyper},
  journal={Biomaterials},
  year={2011},
  volume={32 1},
  pages={195-205}
}
The in vitro labelling of cultured cells with iron oxide nanoparticles (NPs) is a frequent practice in biomedical research. To date, the potential cytotoxicity of these particles remains an issue of debate. In the present study, 4 different NP types (dextran-coated Endorem, carboxydextran-coated Resovist, lipid-coated magnetoliposomes (MLs) and citrate-coated very small iron oxide particles (VSOP)) are tested on a variety of cell types, being C17.2 neural progenitor cells, PC12 rat… CONTINUE READING