Cytotoxic effects of hydroxylated fullerenes on isolated rat hepatocytes via mitochondrial dysfunction

@article{Nakagawa2011CytotoxicEO,
  title={Cytotoxic effects of hydroxylated fullerenes on isolated rat hepatocytes via mitochondrial dysfunction},
  author={Yoshio Nakagawa and Toshinari Suzuki and Hidemi Ishii and Dai Nakae and Akio Ogata},
  journal={Archives of Toxicology},
  year={2011},
  volume={85},
  pages={1429-1440}
}
The cytotoxic effects of hydroxylated fullerenes, also termed fullerenols or fullerols [C60(OH) n ], which are known nanomaterials and water-soluble fullerene derivatives, were studied in freshly isolated rat hepatocytes. The exposure of hepatocytes to C60(OH)24 caused not only concentration (0–0.25 mM)- and time (0–3 h)-dependent cell death accompanied by the formation of cell blebs, loss of cellular ATP, reduced glutathione (GSH), and protein thiol levels, but also the accumulation of… CONTINUE READING

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