Cytotoxic effects of gammadelta T cells expanded ex vivo by a third generation bisphosphonate for cancer immunotherapy.

@article{Sato2005CytotoxicEO,
  title={Cytotoxic effects of gammadelta T cells expanded ex vivo by a third generation bisphosphonate for cancer immunotherapy.},
  author={Kiyoshi Sato and Shinya Kimura and Hidekazu Segawa and Asumi Yokota and Seiji Matsumoto and Junya Kuroda and Masaki Nogawa and Takeshi Yuasa and Yasushi Kiyono and Hiromi Wada and Taira Maekawa},
  journal={International journal of cancer},
  year={2005},
  volume={116 1},
  pages={94-9}
}
Nitrogen containing-bisphosphonates (N-BPs), widely used to treat bone diseases, have direct antitumor effects via the inactivation of Ras proteins. In addition to the direct antitumor activities, N-BPs expand gammadeltaT cells, which exhibit major histocompatibility complex-unrestricted lytic activity. BPs accumulate intermediate metabolites which may be… CONTINUE READING