Cytotoxic effects and oxidative stress response of six PBDE metabolites on human L02 cells.

@article{Zhong2011CytotoxicEA,
  title={Cytotoxic effects and oxidative stress response of six PBDE metabolites on human L02 cells.},
  author={Yu Fang Zhong and Liu Wang and Ling Ling Yin and Jing An and Mei Ling Hou and Ke Zheng and Xin Yong Zhang and Ming Hua Wu and Zhi Qiang Yu and Guo ying Sheng and Jia Mo Fu},
  journal={Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering},
  year={2011},
  volume={46 12},
  pages={
          1320-7
        }
}
In the present study, the cytotoxic effects and toxicological mechanism of six polybrominated diphenyl ethers (PBDEs) metabolites (3-OH-BDE47, 3-MeO-BDE47, 5-OH-BDE47, 5-MeO-BDE47, 6-OH-BDE85 and 6-MeO-BDE85) on L02 cells were explored by investigating the cell viability, apoptosis, lactic dehydrogenase (LDH) leakage, and oxidative stress response. The results showed that these metabolites could inhibit cell proliferation and induce apoptosis, among which 6-OH-BDE85 had the highest efficiency… CONTINUE READING