Cytotoxic effects and in vitro reversal of multidrug resistance by therapeutic ultrasound in human hepatocarcinoma cell line (HepG2).

@article{Shao2008CytotoxicEA,
  title={Cytotoxic effects and in vitro reversal of multidrug resistance by therapeutic ultrasound in human hepatocarcinoma cell line (HepG2).},
  author={Ze-yong Shao and Bao-jin Zhai and Chun-liang Zhao and Kai Hu and Ding-ming Shen and Feng Wu},
  journal={Ultrasonics},
  year={2008},
  volume={48 4},
  pages={297-302}
}
Multidrug resistance (MDR) is one of the major obstacles to successful chemotherapy of human malignancies. Although many strategies have been explored to overcome MDR, none of them have been proven to be clinically useful until now. The aim of this study was to investigate whether a novel therapeutic ultrasound (US) approach would have useful effects on the reversal of MDR in cancer cells. Wild-type and MDR phenotype (HepG2/ADM) cells of the human hepatocarcinoma cell line HepG2 were exposed to… CONTINUE READING