Cytotoxic effect and uptake of estramustine in a rat glioma model.

@article{Bergenheim1994CytotoxicEA,
  title={Cytotoxic effect and uptake of estramustine in a rat glioma model.},
  author={A L Bergenheim and J{\"o}rgen Elfverson and P Thomas Gunnarsson and Karin Edman and Magdalena Hartman and Roger Henriksson},
  journal={International journal of oncology},
  year={1994},
  volume={5 2},
  pages={293-9}
}
The cytotoxic effect of estramustine-phosphate (EMP) and the uptake in tumor tissue were investigated in a rat glioma model in vitro and in vivo. EMP, a combination of nornitrogen mustard and 17beta-estradiol, is a cytotoxic drug which main target is assumed to be the microtubule system. EMP and its metabolite estramustine (EaM) have a demonstrated anti-tumorous effect on human glioma cells in vitro. The drug uptake in tumor tissue and subsequently also the cytotoxic effect, is believed to… CONTINUE READING