Cytotoxic diterpenes from Cassipourea madagascariensis from the Madagascar rainforest.

@article{Chaturvedula2006CytotoxicDF,
  title={Cytotoxic diterpenes from Cassipourea madagascariensis from the Madagascar rainforest.},
  author={Venkata Sai Prakash Chaturvedula and Andrew Norris and James Stuart Miller and Fidisoa Ratovoson and Rabodo Andriantsiferana and Vincent Emile Rasamison and David G I Kingston},
  journal={Journal of natural products},
  year={2006},
  volume={69 2},
  pages={
          287-9
        }
}
Bioassay-directed fractionation of ethanol extracts of the roots and leaves of the plant Cassipourea madagascariensis resulted in the isolation of the two new terpenoids cassipourol (1) and cassipouryl acetate (2) in addition to the three known compounds, 3beta,30-dihydroxylup-20(29)-ene (3), 30-hydroxylup-20(29)-en-3-one (4), and combretol (5). The structures of the two new compounds were established on the basis of 1D and 2D NMR spectroscopic data and chemical conversion. All the isolated… 
Anti-proliferative diterpenes from Dacrycarpus imbricatus
TLDR
These two monocyclic diterpenes (1, 2) were tested for their anti-proliferative activity on acute myeloid leukemia (OCI-AML) cells and showed that 1 had significantly anti- Propellerative activity whereas 2 was weakly active.
Structure of constituents isolated from the bark of Cassipourea malosana and their cytotoxicity against a human ovarian cell line
TLDR
The in vitro cytotoxic activities of these compounds against human ovarian cancer cell line TOV21G were evaluated and most compounds showed little activity; however, the methyl derivatives of flavan dimers (1a and 2a) showed higher activity than parent compounds 1 and 2.
Phytochemical and chemotaxonomic study on the leaves of Rhododendron dauricum L
Chemical Constituents of Hedyotis ampliflora
The Hedyotis genus belongs to the Rubiaceae family with some species used in traditional medicine for treatment of inflammation, cancer, and other diseases [1–3]. Hedyotis ampliflora Hance or
Phytochemical screening of two Thai tropical rainforest Dipterocarps : Hopea odorata Roxb. and Dipterocarpus costatus Gaertn.f.
Preliminary study of the extracts from Hopea odorata leaves and Dipterocarpus costatus wood showed that the hexane extracts of both plants exhibited cytotoxicity against breast cancer (MCF-7) and
...
1
2
3
...

References

SHOWING 1-8 OF 8 REFERENCES
Cytotoxic flavanones of Schizolaena hystrix from the Madagascar rainforest.
TLDR
Nymphaeol A (IC(50) = 5.5 microg/mL) exhibited the greatest cytotoxicity, while the other flavanones were found to be only weakly active.
New cytotoxic oleanane saponins from the infructescences of Polyscias amplifolia from the Madagascar rainforest.
TLDR
All the isolated compounds showed weak cytotoxicity against A2780 human ovarian cancer cell line, with IC50 values in the range 6.7 to 10.8 microg/mL.
Ipomoeassins A-E, cytotoxic macrocyclic glycoresins from the leaves of Ipomoea squamosa from the Suriname rainforest.
TLDR
The new glycoresins, ipomoeassins A-E (1-5), have been isolated from the leaves of Ipomoea squamosa by spectroscopic analyses and chemical transformations and showed the highest activity in the A2780 human ovarian cancer cell line assay.
New eudesmane derivatives from Melampodium camphoratum from the Suriname rainforest.
Bioassay-guided fractionation of an EtOAc extract of the leaves of Melampodium camphoratum using an assay for inhibitors of the degradation of hemin resulted in the isolation of six new eudesmane
Cassipoureamide-A and -B: new sulfur-containing amides from stem wood of Cassipourea guianensis.
TLDR
Two new sulfur-containing amides, cassipoureamide-A and -B, have been isolated from the stem wood of Cassipourea guianensis, and their structures were determined to be cis-N-(2-hydroxyethyl)-4-Hydroxy-1,2-dithiolane-3-carboxamide and cis- N-(2,2,3-trithiane-4- carboxamide, respectively.
Radiation survival parameters of antineoplastic drug-sensitive and -resistant human ovarian cancer cell lines and their modification by buthionine sulfoximine.
TLDR
The results suggest that the sequential use of irradiation following chemotherapy with melphalan and cisplatin may be less effective than a combined modality approach, which integrates radiation and chemotherapy prior to the development of drug resistance and cross-resistance to irradiation.
Occurrence of gerrardine in Cassipourea guianensis.