Cytotoxic cyclolignans related to podophyllotoxin.

@article{Gordaliza2001CytotoxicCR,
  title={Cytotoxic cyclolignans related to podophyllotoxin.},
  author={Marina Gordaliza and Jos{\'e} Maria Miguel del Corral and M Angeles Castro and Pedro Garc{\'i}a-Garc{\'i}a and Arturo San Feliciano},
  journal={Farmaco},
  year={2001},
  volume={56 4},
  pages={297-304}
}
The cyclolignan family of natural products includes compounds with important antineoplastic and antiviral properties such as podophyllotoxin and two of their semisynthetic derivatives, etoposide and teniposide. The latter are included in a wide variety of cancer chemotherapy protocols. Due to these biological activities, cyclolignans have been the objective of numerous studies focused to prepare better and safer anticancer drugs. Several cyclolignans related to podophyllotoxin have been… CONTINUE READING