Cytotoxic constituents from the stem bark of Diospyros cuneata Standl.

  title={Cytotoxic constituents from the stem bark of Diospyros cuneata Standl.},
  author={Carlos Quintal-Novelo and Rosa Esther Moo-Puc and Juan Chal{\'e}-Dzul and Mirbella C{\'a}ceres-Farf{\'a}n and Martha M{\'e}ndez-Gonz{\'a}lez and Roc{\'i}o Borges-Arg{\'a}ez},
  journal={Natural Product Research},
  pages={1594 - 1597}
A phytochemical investigation of the stem bark of Diospyros cuneata (Ebenaceae) together with in vitro cytotoxic evaluation of the pure compounds in four human cancer cell lines KB, Hep-2, HeLa and SiHa led to the isolation of plumbagin, elliptinone, lupeol, atraric acid methyl ester, maritinone, betulin and betulinaldehyde. The structural determination of the compounds was established by nuclear magnetic resonance, electron ionisation mass spectrometric analysis as well as comparison with data… 
6 Citations
Diospyros, an under-utilized, multi-purpose plant genus: A review.
The Triterpenoid Betulin Protects against the Neuromuscular Effects of Bothrops jararacussu Snake Venom In Vivo
Results indicate that betulin given i.p. has a similar efficacy in attenuating the neuromuscular effects of B. jararacussu venom in vivo and could be a useful complementary measure to antivenom therapy for treating snakebite.
A hexa-herbal Chinese formula for treatment of atopic dermatitis : phytochemical analysis and selected anti-inflammatory activities
Results showed that the HHCF inhibited hyaluronidase activity, TNF-α- plus IFN--induced CCL17 production in spontaneously immortalized human epidermal keratinocytes (HaCaT) and IL-1β-induced PGE2 in human fibroblasts with no effects on IL-8 andIL- 6.


Lupeol long-chain fatty acid esters with antimalarial activity from Holarrhena floribunda.
An ethnopharmacological investigation was conducted among the Baka pygmies of Dja biosphere reserve (Cameroon) to collect information on the antimalarial plants used in their daily life, and extracts of H. floribunda showed remarkable inhibitory activity against drug-resistant strains of Plasmodium falciparum.
Pharmacological properties of the ubiquitous natural product betulin.
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
Bioactivity-directed fractionation of extracts of two Diospyros maritima bark samples from Indonesia yielded a diverse set of secondary metabolites, including a new naphthoquinone derivative, (4S)-shinanolone, and a new natural product coumarin.
In vitro cytotoxicity activity of diosquinone, a naphthoquinone epoxide
Diosquinone, a naphthoquinone epoxide previously isolated from the root bark of Diospyros mespiliformis and D. tricolor is assessed for cytotoxicity activity against ten cancer cell lines by standard NIH method, suggesting its probable cytot toxicity activity.
Triterpenoids and diarylheptanoids from alnus hirsuta inhibit HIF-1 in ags cells
Bioassay-guided fractionation and purification of the EtOAc soluble fraction from the MeOH extract of the stem bark of Alnus hirsuta (Betulaceae), using an in vitro HIF-1 assay, led to the isolation
Activity-guided isolation of an antiandrogenic compound of Pygeum africanum.
Bioactivity-directed fractionation of a selective dichloromethane extract from the stem bark of Pygeum africanum led to the isolation of the anti androgenic compound atraric acid, which was transformed into its ethyl, N-propyl and N-butyl esters and their antiandrogenic activities were examined.
Induction of apoptosis by plumbagin through reactive oxygen species-mediated inhibition of topoisomerase II.