Identification of a Triterpenoid as a Novel PPARγ Activator Derived from Formosan Plants
- Chemistry, BiologyPhytotherapy research : PTR
Peroxisome proliferator‐activated receptor γ (PPARγ), one of the transcription factors that regulate lipid metabolism and energy use in tumor cells, is a viable target for cancer therapy. In our…
An extensive review on phytochemistry and pharmacological activities of Indian medicinal plant Celastrus paniculatus Willd
- BiologyPhytotherapy research : PTR
The objective of this review article is to discuss the reported ethnopharmacological uses, phytochemistry and various pharmacological activities of C. paniculatus with different extracts of this plant as well as various phytoconstituents present in this plant.
Compounds From Celastraceae Targeting Cancer Pathways and Their Potential Application in Head and Neck Squamous Cell Carcinoma: A Review
- Biology, MedicineCurrent genomics
This review reports studies on chemical constituents isolated from species from the Celastraceae family targeting cancer mechanisms studied to date correlated with molecular characteristics of head and neck squamous cell carcinoma in an attempt to identify constituents with potential application in the treatment of this complex disease at the molecular level.
Untangling knots between autophagic targets and candidate drugs, in cancer therapy
- Biology, ChemistryCell proliferation
New discoveries of related small molecules or chemical compounds that can regulate autophagic pathways and lead to pro‐death or pro‐survival autophagy, in different types of cancer are revealed.
Celastrus paniculatus Willd. mitigates t-BHP induced oxidative and apoptotic damage in C2C12 murine muscle cells
Overall the extract inhibits the muscle cell damage, thus explaining the possible anti-oxidant/anti-apoptotic defense status of the C. paniculatus seed extract.
A Review on Medicinal Plants as a Potential Source for Cancer
This article considers 82 medicinal plants belonging to 46 families and information on the Botanical name, family name, parts used, experimental model and mechanism of action were presented and basic handful information is provided for researchers who are interested to work on medicinal plants for innovation of active biological compounds that toWork on cancer as a principle mechanism.