• DOI:10.1021/NP0605034
Corpus ID: 43257846

Cytotoxic clerodane diterpenoids and their hydrolysis products from Casearia nigrescens from the rainforest of Madagascar.

@article{Williams2007CytotoxicCD,
  title={Cytotoxic clerodane diterpenoids and their hydrolysis products from Casearia nigrescens from the rainforest of Madagascar.},
  author={Russell B Williams and A. Norris and J. S. Miller and C. Birkinshaw and F. Ratovoson and Rabodo Andriantsiferana and V. Rasamison and D. Kingston},
  journal={Journal of natural products},
  year={2007},
  volume={70 2},
  pages={
          206-9
        }
}

Russell B Williams, A. Norris, +5 authors D. Kingston

Published 2007

Biology, Medicine

Journal of natural products

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Bioassay-guided fractionation of the cytotoxic leaf and flower extract of Casearia nigrescens led to the isolation of four new clerodane diterpenoids, designated caseanigrescens A-D (1-4). These compounds were subject to hydrolysis to dialdehydes when stored in CDCl3. The structures of compounds 1-4 were determined using 1D and 2D NMR spectroscopy. All four compounds showed moderate cytotoxicity to the A2780 human ovarian cancer cell line, with an IC50 range of 0.83-1.4 microM.