Cytotoxic clerodane diterpenoids and their hydrolysis products from Casearia nigrescens from the rainforest of Madagascar.

@article{Williams2007CytotoxicCD,
  title={Cytotoxic clerodane diterpenoids and their hydrolysis products from Casearia nigrescens from the rainforest of Madagascar.},
  author={Russell B Williams and A. Norris and J. S. Miller and C. Birkinshaw and F. Ratovoson and Rabodo Andriantsiferana and V. Rasamison and D. Kingston},
  journal={Journal of natural products},
  year={2007},
  volume={70 2},
  pages={
          206-9
        }
}
  • Russell B Williams, A. Norris, +5 authors D. Kingston
  • Published 2007
  • Biology, Medicine
  • Journal of natural products
  • Bioassay-guided fractionation of the cytotoxic leaf and flower extract of Casearia nigrescens led to the isolation of four new clerodane diterpenoids, designated caseanigrescens A-D (1-4). These compounds were subject to hydrolysis to dialdehydes when stored in CDCl3. The structures of compounds 1-4 were determined using 1D and 2D NMR spectroscopy. All four compounds showed moderate cytotoxicity to the A2780 human ovarian cancer cell line, with an IC50 range of 0.83-1.4 microM. 
    43 Citations
    Clerodane diterpenoids from Casearia kurzii and their cytotoxic activities
    • 1
    A New Cytotoxic Clerodane Diterpene from Casearia Graveolens Twigs
    • 3
    Cytotoxic clerodane diterpenes from Casearia rupestris.
    • 32
    Bioactive clerodane diterpenoids from the twigs of Casearia balansae.
    • 24
    Cytotoxic diterpenoids as potential anticancer agents from the twigs of Casearia kurzii.
    • 4
    Bioactive Diterpenoids from the Leaves of Callicarpa macrophylla.
    • 24
    Diterpenoids from the leaves of Casearia kurzii showing cytotoxic activities.
    • 1
    Cytotoxic clerodane diterpenoids from the leaves of Casearia kurzii.
    • 7
    Cytotoxic clerodane diterpenes from Zuelania guidonia.
    • 14
    Cytotoxic Clerodane Diterpenoids from the Leaves of Casearia grewiifolia.
    • 8