Cytotoxic clerodane diterpenes from Casearia rupestris.

  title={Cytotoxic clerodane diterpenes from Casearia rupestris.},
  author={Gerardo M Vieira-J{\'u}nior and Luiz Ant{\^o}nio Dutra and Paulo Michel Pinheiro Ferreira and Manoel Odor{\'i}co de Moraes and Let{\'i}cia Veras Costa Lotufo and Cl{\'a}udia do {\'O}. Pessoa and Roseli Buzanelli Torres and Nivaldo Boralle and Vanderlan da Silva Bolzani and Alberto Jos{\'e} Cavalheiro},
  journal={Journal of natural products},
  volume={74 4},
Four new clerodane diterpenes, casearupestrins A-D (1-4), were isolated from the leaves of Casearia rupestris. Compounds 1 and 4 were acetylated to yield 2,7-di-O-acetylcasearupestrin A (5) and 2,6-di-O-acetylcasearupestrin D (6). All compounds were evaluated for cytotoxicity against a small panel of human cancer cell lines. Casearupestrin A (1) exhibited the most potent activity against MDA/MB-435 (human melanoma) and SF-295 (human glioblastoma) cells, superior to that of the standard drug… CONTINUE READING

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