Cytotoxic caffeic acid derivatives from the rhizomes of Cimicifuga heracleifolia.

@article{Yim2012CytotoxicCA,
  title={Cytotoxic caffeic acid derivatives from the rhizomes of Cimicifuga heracleifolia.},
  author={Soon-Ho Yim and Hyun Jung Kim and Si-Hwan Park and Jinmi Kim and Darren R Williams and Da-Woon Jung and Ik-Soo Lee},
  journal={Archives of pharmacal research},
  year={2012},
  volume={35 9},
  pages={1559-65}
}
Activity profiling of the n-BuOH extract from Cimicifuga heracleifolia rhizomes led to the identification of three cytotoxic caffeic acid derivatives, carboxymethyl isoferulate (2), cimicifugic acid A (3), and cimicifugic acid B (4) together with a series of structurally related inactive compounds. The extract was separated by time-based fractionation in a gradient HPLC condition, and cytotoxicity of each fraction was evaluated using HCT116 colon cancer cells in vitro. HPLChyphenated… CONTINUE READING