Cytotoxic aporphine alkaloids from Cassytha filiformis.

  title={Cytotoxic aporphine alkaloids from Cassytha filiformis.},
  author={Caroline St{\'e}vigny and S{\'e}bastien Block and M. C. De Pauw-Gillet and Edmond de Hoffmann and Gabriel Llabr{\`e}s and Victor Adjakidj{\'e} and Jo{\"e}lle Quetin-Leclercq},
  journal={Planta medica},
  volume={68 11},
Purification of a cytotoxic crude alkaloid extract of Cassytha filiformis led to the isolation of four known aporphine alkaloids: neolitsine, dicentrine, cassythine (= cassyfiline) and actinodaphnine. Their structures were determined by analysis of spectroscopic data. All isolated alkaloids were tested for their cytotoxic activities on cancer and non-cancer cell lines in vitro. Neolitsine was the most active against HeLa and 3T3 cells (IC 50 :21.6 microM, and 21.4 microM, respectively… CONTINUE READING
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