Cytotoxic anthraquinone derivatives from Picramnia antidesma.

Abstract

Activity-guided investigation of crude extracts prepared from the root bark of Picramnia antidesma, a medicinal plant long used for the treatment of malaria in tropical areas of the Americas, when tested on KB cells led to the isolation of a new compound, 10-epi-uveoside, from a cytotoxic fraction containing a rich mixture of anthrone glycosides. The antiplasmodial activity proved to be a result of the high levels of cytotoxicity displayed by the anthraquinone derivatives and therefore infusions from this crude drug lack the selectivity index needed to be an effective antimalarial agent.

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@article{HernndezMedel2002CytotoxicAD, title={Cytotoxic anthraquinone derivatives from Picramnia antidesma.}, author={Mar{\'i}a del Rosario Hern{\'a}ndez-Medel and Rogelio Pereda-Miranda}, journal={Planta medica}, year={2002}, volume={68 6}, pages={556-8} }