Cytotoxic and protective DNA damage of three new diterpenoids from the brown alga Dictoyota dichotoma.

@article{Ayyad2011CytotoxicAP,
  title={Cytotoxic and protective DNA damage of three new diterpenoids from the brown alga Dictoyota dichotoma.},
  author={S N Ayyad and Mohamed Saleh Makki and Nazeeha S Al-Kayal and Salim A. Basaif and Kalid O El-Foty and Abdullah M. Asiri and Walied Mohamed Alarif and Farid Abdel-Rahem Badria},
  journal={European journal of medicinal chemistry},
  year={2011},
  volume={46 1},
  pages={175-82}
}
Three new diterpenes Amijiol acetate (3), dolabellane, Dolabellatrienol (4), and dolastane, Amijiol-7, 10-diacetate (9) were isolated together with the previously described Pachydictyol A (1), Isopachydictyol A (2), 8β-hydroxypachydictyol A (5), Amijiol (6), Isodictyohemiacetal (7) and Dictyol C (8) from the Red Sea brown alga Dictyota dichotoma var. implexa. The structures and relative stereochemistry of the new diterpenoids were proposed on the basis of their spectral data. Compounds 3 and 9… CONTINUE READING

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