Cytotoxic and mutagenic properties of regioisomeric O²-, N3- and O⁴-ethylthymidines in bacterial cells.

@article{Zhai2014CytotoxicAM,
  title={Cytotoxic and mutagenic properties of regioisomeric O²-, N3- and O⁴-ethylthymidines in bacterial cells.},
  author={Qianqian Zhai and Pengcheng Wang and Yinsheng Wang},
  journal={Carcinogenesis},
  year={2014},
  volume={35 9},
  pages={2002-6}
}
Exposure to environmental agents and endogenous metabolism can both give rise to DNA alkylation. Thymine is known to be alkylated at O(2), N3 and O(4) positions; however, it remains poorly explored how the regioisomeric alkylated thymidine lesions compromise the flow of genetic information by perturbing DNA replication in cells. Herein, we assessed the… CONTINUE READING