Cytotoxic and cytostatic effects induced by 4-hydroxynonenal in human osteosarcoma cells.

Abstract

Several studies point to the existence of an inverse correlation between cellular lipid peroxidation and both cell proliferation and neoplastic transformation. Furthermore, numerous results demonstrate that lipid peroxidation products affect central biochemical pathways and intracellular signalling at physiological concentrations. 4-Hydroxynonenal (HNE) is… (More)

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@article{Calonghi2002CytotoxicAC, title={Cytotoxic and cytostatic effects induced by 4-hydroxynonenal in human osteosarcoma cells.}, author={Natalia Calonghi and Carla Boga and Concettina Cappadone and Eleonora Pagnotta and Carlo Bertucci and Jessica Fiori and Lanfranco Masotti}, journal={Biochemical and biophysical research communications}, year={2002}, volume={293 5}, pages={1502-7} }