Cytotoxic and apoptosis-inducing activities of limonoids from the seeds of Azadirachta indica (neem).

@article{Kikuchi2011CytotoxicAA,
  title={Cytotoxic and apoptosis-inducing activities of limonoids from the seeds of Azadirachta indica (neem).},
  author={Takashi Kikuchi and Koichi Ishii and Taisuke Noto and Akitomo Takahashi and Keiichi Tabata and Takashi Suzuki and Toshihiro Akihisa},
  journal={Journal of natural products},
  year={2011},
  volume={74 4},
  pages={866-70}
}
Thirty-five limonoids, including 15 of the azadiradione type (1-15), five of the gedunin type (16-20), four of the azadirachtin type (21-24), nine of the nimbin type (25-33), and two degraded limonoids (34, 35), isolated from Azadirachta indica seed extracts, were evaluated for their cytotoxic activities against five human cancer cell lines. Seven compounds (3, 6, 7, 16, 18, 28, and 29) exhibited cytotoxic activity against one or more cell lines. Among these compounds, 7-deacetyl-7… CONTINUE READING

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