Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica.

@article{Nguyen2009CytotoxicAP,
  title={Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica.},
  author={Phi Hung Nguyen and Thi Van Thu Le and Phuong Thien Thuong and Trong Tuan Dao and Derek T. Ndinteh and Joseph Tanyi Mbafor and Keon Wook Kang and Won Keun Oh},
  journal={Bioorganic & medicinal chemistry letters},
  year={2009},
  volume={19 23},
  pages={6745-9}
}
Bioassay-guided fractionation of the EtOAc extract of the stem bark of Erythrina abyssinica (Leguminosae) resulted in the isolation of three new (1-3), along with 12 known (4-15) pterocarpan derivatives. Their chemical structures were determined by physicochemical and spectroscopic data analysis (IR, UV, [alpha](D), CD, 1D and 2D NMR, and MS data). All the isolates were evaluated for their inhibitory effects on protein tyrosine phosphatase-1B (PTP1B), as well as their growth inhibition on MCF7… CONTINUE READING

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