Cytotoxic acyl amides from the soil fungus Gymnascella dankaliensis.

@article{Hammerschmidt2015CytotoxicAA,
  title={Cytotoxic acyl amides from the soil fungus Gymnascella dankaliensis.},
  author={Lena Hammerschmidt and Amal H. Aly and Mohammed Abdel-Aziz and Werner E. G. M{\"u}ller and Wenhan Lin and Georgios Daletos and Peter Proksch},
  journal={Bioorganic \& medicinal chemistry},
  year={2015},
  volume={23 4},
  pages={
          712-9
        }
}
View on PubMed
doi.org
21 Citations
Highly Influential Citations
1
Background Citations
2
Methods Citations
1

Figures and Tables from this paper

21 Citations

Targeted solid phase fermentation of the soil dwelling fungus Gymnascella dankaliensis yields new brominated tyrosine-derived alkaloids
Seven new brominated tyrosine-derived alkaloids, gymnastatins T–Y (1–6) and dankastatin D (7), together with three known likewise brominated analogues gymnastatins I–K (8–10) were isolated from the…
Induction of New Lactam Derivatives From the Endophytic Fungus Aplosporella javeedii Through an OSMAC Approach
TLDR
Chemical investigation of the former fungal extracts yielded 11 new lactam derivatives, aplosporellins A–K (2–12), in addition to the known compound, pramanicin A (1), indicating the power of this OSMAC approach.
Expanding the chemical diversity of an endophytic fungus Bulgaria inquinans, an ascomycete associated with mistletoe, through an OSMAC approach
An endophytic fungus Bulgaria inquinans (isolate MSp3-1), isolated from mistletoe (Viscum album), was subjected to fermentation on solid Czapek medium. Chromatographic workup of the crude EtOAc…
Induction of ambuic acid derivatives by the endophytic fungus Pestalotiopsis lespedezae through an OSMAC approach
Xanthones and sesquiterpene derivatives from a marine-derived fungus Scopulariopsis sp.
OSMAC approach leads to new fusarielin metabolites from Fusarium tricinctum
TLDR
The highest increase in the accumulation of compound 1 was observed in the presence of apple and carrot juice, whereas the stimulating effect was weaker for banana juice, and cytotoxicity against the human ovarian cancer cell line A2780 was observed.
Secondary Metabolites from Fungi: Natural Product Diversity, Structure Elucidation and Bioactivity
IV Abstract This dissertation describes secondary metabolites isolated from different fungi, including Trichoderma harzianum, Aspergillus terreus, Penicillium sp. (strains IO1 and IO2), Alternaria…
Chemical investigations into the biosynthesis of the gymnastatin and dankastatin alkaloids†
TLDR
It is found that multiple natural products can also be formed from aranorosin, a non-halogenated natural product also produced by Gymnascella sp.
Secondary Metabolites of Onygenales Fungi Exemplified by Aioliomyces pyridodomos.
TLDR
A large biosynthetic potential is delineated in Aioliomyces pyridodomos, the first representative of a candidate new family within Onygenales, which isolated 14 new bioactive metabolites and thirty-two specialized metabolite biosynthesis gene clusters were identified.
Metabolites from the Marine-Facultative Aspergillus sp. MEXU 27854 and Gymnoascus hyalinosporus MEXU 29901 from Caleta Bay, Mexico.
...
...

References

SHOWING 1-10 OF 43 REFERENCES
Protein kinase and HDAC inhibitors from the endophytic fungus Epicoccum nigrum.
TLDR
Interestingly, compounds 1 and 10 exert mainly cytostatic effects in human lymphoma RAJI and U-937 cell lines.
Gymnastatins F-H, cytostatic metabolites from the sponge-derived fungus Gymnascella dankaliensis.
TLDR
Among these compounds, gymnastatins F and G possess a unique bicyclo[3.3.1]nonane ring as natural products, and they were found to exhibit potent growth inhibition against the P388 cancer cell line.
Bioactive isoquinoline alkaloids from Corydalis saxicola.
TLDR
Structural-activity studies demonstrated that the nitro substituents at ring A in the tetrahydroprotoberberines led to an increase in the anti-acetylcholinesterase activity.
One strain-many compounds (OSMAC) method for production of polyketides, azaphilones, and an isochromanone using the endophytic fungus Dothideomycete sp.
Farinosones A-C, neurotrophic alkaloidal metabolites from the entomogenous deuteromycete Paecilomyces farinosus.
Two new yellow pigments, farinosones A (1) and B (2), were isolated from the mycelial extract of the entomogenous fungal strain Paecilomyces farinosus RCEF 0101, together with farinosone C (3), a new…
Spiromastixones A-O, antibacterial chlorodepsidones from a deep-sea-derived Spiromastix sp. fungus.
Fifteen new depsidone-based analogues named spiromastixones A-O (1-15) were isolated from the fermentation broth of a deep-sea Spiromastix sp. fungus. Their structures were elucidated on the basis of…
Isolation and total synthesis of gymnastatin N, a POLO-like kinase 1 active constituent from the fungus Arachniotus punctatus
Production of the cytostatic agent aeroplysinin by the sponge Verongia aerophoba in in vitro culture.
Caryophyllene sesquiterpenes from the marine-derived fungus Ascotricha sp. ZJ-M-5 by the one strain-many compounds strategy.
TLDR
It can be concluded that modification of the culture media is still effective in the discovery of novel bioactive fungal secondary metabolites.
Kahalalide derivatives from the Indian sacoglossan mollusk Elysia grandifolia.
TLDR
The new derivative kahalalide R was found to exert comparable or even higher cytotoxicity than the potential drug candidate kahAlalide F toward the MCF7 human mammary carcinoma cell line.
...
...