Cytotoxic activity of nucleoside diphosphate kinase secreted from Mycobacterium tuberculosis.

@article{Chopra2003CytotoxicAO,
  title={Cytotoxic activity of nucleoside diphosphate kinase secreted from Mycobacterium tuberculosis.},
  author={Puneet Chopra and Anubha Singh and Anil Koul and Srinivasan Ramachandran and Karl Drlica and Anil K Tyagi and Yogendra Singh},
  journal={European journal of biochemistry},
  year={2003},
  volume={270 4},
  pages={625-34}
}
Pathogenicity of Mycobacterium tuberculosis is closely related to its ability to survive and replicate in the hostile environment of macrophages. For some pathogenic bacteria, secretion of ATP-utilizing enzymes into the extracellular environment aids in pathogen survival via P2Z receptor-mediated, ATP-induced death of infected macrophages. A component of these enzymes is nucleoside diphosphate kinase (Ndk). The ndk gene was cloned from M. tuberculosis H37Rv and expressed in Escherichia coli… CONTINUE READING

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