Cytotoxic activity of Perilla frutescens var. japonica leaf extract is due to high concentrations of oleanolic and ursolic acids

@article{Akihisa2006CytotoxicAO,
  title={Cytotoxic activity of Perilla frutescens var. japonica leaf extract is due to high concentrations of oleanolic and ursolic acids},
  author={Toshihiro Akihisa and Satoshi Kamo and Taketo Uchiyama and Hiroyuki Akazawa and Norihiro Banno and Yosuke Taguchi and Ken Yasukawa},
  journal={Journal of Natural Medicines},
  year={2006},
  volume={60},
  pages={331-333}
}
Three triterpene acids, ursolic acid (1), corosolic acid (2), and oleanolic acid (7), were isolated from the ethanol extract of leaves of Perilla frutescens (L.) Britton var. japonica Hara (Labiatae; Japanese name: Egoma). These acids are the active principles responsible for the cytotoxicity against three cultured human tumor cell lines, HL-60 (leukemia… CONTINUE READING