Cytotoxic activities of several geranyl-substituted flavanones.

  title={Cytotoxic activities of several geranyl-substituted flavanones.},
  author={Karel {\vS}mejkal and Jana Sva{\vc}inov{\'a} and Tereza Slapetov{\'a} and Krist{\'y}na Schneiderov{\'a} and Stefano Dall'Acqua and Gabbriella Innocenti and Veronika M{\"u}ller Z{\'a}valov{\'a} and Peter Kollar and Stanislav Chud{\'i}k and Radek Marek and Ondřej Jul{\'i}nek and Marie Urbanov{\'a} and Murat Emre Kartal and Marek Cs{\"o}llei and Karel Dole{\vz}al},
  journal={Journal of natural products},
  volume={73 4},
Nine geranylated flavanones isolated from the fruits of Paulownia tomentosa (4-12) and two from the roots of Morus alba (13 and 14) were examined for cytotoxicity to selected human cancer cell lines and normal human fibroblasts. Cytotoxicity was determined in vitro using a calcein AM cytotoxicity assay. Cytotoxicity for the THP-1 monocytic leukemia cell line was tested using erythrosin B cell staining. The geranylated compounds tested were compared with the known simple flavanone standards… CONTINUE READING