Cytotoxic T lymphocytes directed to the preferentially expressed antigen of melanoma (PRAME) target chronic myeloid leukemia.

@article{Quintarelli2008CytotoxicTL,
  title={Cytotoxic T lymphocytes directed to the preferentially expressed antigen of melanoma (PRAME) target chronic myeloid leukemia.},
  author={Concetta Quintarelli and Gianpietro Dotti and Biagio De Angelis and Valentina Hoyos and Martha Mims and Luigia Luciano and Helen E Heslop and Cliona M Rooney and Fabrizio Pane and Barbara Savoldo},
  journal={Blood},
  year={2008},
  volume={112 5},
  pages={1876-85}
}
The cancer testis antigen (CTA) preferentially expressed antigen of melanoma (PRAME) is overexpressed in many hematologic malignancies, including chronic myeloid leukemia (CML). The sensitivity of CML to donor lymphocyte infusion after allogeneic stem cell transplantation suggests this tumor can be highly susceptible to cellular immunotherapy targeted to tumor associated antigens. We therefore tested whether functional PRAME-specific cytotoxic T lymphocytes (PRAME CTLs) could be generated and… CONTINUE READING
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