Cytotoxic T lymphocyte recognition of a xenogeneic major histocompatibility complex antigen expressed in transgenic mice.

@article{Bluestone1987CytotoxicTL,
  title={Cytotoxic T lymphocyte recognition of a xenogeneic major histocompatibility complex antigen expressed in transgenic mice.},
  author={Jeffrey A Bluestone and Mark D. Pescovitz and William I. Frels and Dinah Singer and R J Hodes},
  journal={European journal of immunology},
  year={1987},
  volume={17 7},
  pages={1035-41}
}
Introduction of a porcine major histocompatability complex (MHC) class I gene (PD1) into the genome of a C57BL/10 (B10) mouse has been shown to lead to cell surface expression of the porcine MHC antigen, SLAPD1 in a transgenic mouse. The PD1 product expressed on spleen cells from the transgenic mice stimulated B10 spleen cells in a mixed lymphocyte culture… CONTINUE READING