Cytotoxic T lymphocyte precursor frequency analyses in bone marrow transplantation with volunteer unrelated donors. Value in donor selection.

@article{Spencer1995CytotoxicTL,
  title={Cytotoxic T lymphocyte precursor frequency analyses in bone marrow transplantation with volunteer unrelated donors. Value in donor selection.},
  author={Andrew Spencer and Paul A. Brookes and Edward Kaminski and Jill M Hows and Richard M. Szydlo and Frits van Rhee and J M Goldman and J. Richard Batchelor},
  journal={Transplantation},
  year={1995},
  volume={59 9},
  pages={
          1302-8
        }
}
Between May 1989 and February 1994, we performed 48 volunteer unrelated donor BMTs for first chronic phase chronic myeloid leukemia using in vivo T cell depletion for acute graft-versus-host disease (aGvHD) prophylaxis. In 40 cases, adequate material was available to measure the frequency of antirecipient MHC cytotoxic T lymphocyte precursor (CTLp) cells in the blood of potential donors. This supplemented standard serological typing, one-dimensional isoelectric focusing for class I proteins… CONTINUE READING
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