Cytotoxic T-lymphocyte-mediated killing of human pancreatic islet cells in vitro.

Abstract

Cytotoxic T lymphocytes (CTL) are believed to play an essential role in beta-cell destruction leading to development of type 1 diabetes and allogeneic islet graft failure. We aimed to identify the mechanisms used by CTL to kill human beta cells. CTL clones that recognize epitopes from influenza virus and Epstein-Barr virus restricted by human leukocyte… (More)
DOI: 10.1016/j.humimm.2008.06.008

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@article{Campbell2008CytotoxicTK, title={Cytotoxic T-lymphocyte-mediated killing of human pancreatic islet cells in vitro.}, author={Peter D. Campbell and Eugene Estella and Nadine L. Dudek and Gaurang Jhala and Helen Thomas and Thomas W H Kay and Stuart I Mannering}, journal={Human immunology}, year={2008}, volume={69 9}, pages={543-51} }