Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes

  title={Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes},
  author={Peter J Peters and Jannie Borst and Viola Oorschot and Minoru Fukuda and O P Kr{\"a}henb{\"u}hl and J{\"u}rg Tschopp and Jan W. Slot and Hans J. Geuze},
  journal={The Journal of Experimental Medicine},
  pages={1099 - 1109}
Cytotoxic T lymphocytes (CTL) contain granules that are exocytosed during specific interaction with target cells (TC). In this process, the granule contents, including the lethal protein perforin, as well as granzymes, a family of serine esterases, are delivered to the TC. Information regarding the routing of these proteins towards the granule and their exact localization within the granule is of primary importance to resolve the mechanism of granule-mediated TC killing. In this study, the… CONTINUE READING
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