Cytotoxic T-lymphocyte-associated antigen-4.

  title={Cytotoxic T-lymphocyte-associated antigen-4.},
  author={F. Stephen Hodi},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={13 18 Pt 1},
  • F. Stephen Hodi
  • Published 2007 in
    Clinical cancer research : an official journal of…
Previously, the development of immune-based therapies has primarily focused on vaccines and cytokines, yielding benefit in a small percentage of patients. Recent advances in our understanding of the function of costimulatory molecules have revitalized enthusiasm in the development of immune therapies for cancer. This family of proteins possesses properties involved in both lymphocyte activation and immune-inhibitory functions. The costimulatory molecule with the greatest translation into the… CONTINUE READING


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