Cytotoxic T lymphocyte associated antigen-4 gene polymorphisms confer susceptibility to primary biliary cirrhosis and autoimmune hepatitis in Chinese population.

@article{Fan2004CytotoxicTL,
  title={Cytotoxic T lymphocyte associated antigen-4 gene polymorphisms confer susceptibility to primary biliary cirrhosis and autoimmune hepatitis in Chinese population.},
  author={Lie-ying Fan and Xiao-qing Tu and Q L Cheng and Ye Sen Zhu and Ralph Feltens and Thomas Pfeiffer and Ren-qian Zhong},
  journal={World journal of gastroenterology},
  year={2004},
  volume={10 20},
  pages={3056-9}
}
AIM To investigate the association between Chinese patients with autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and the polymorphisms of cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) gene promoter (-318) and exon 1 (+49). METHODS CTLA-4 promoter (-318 T/C) and exon1 (+49A/G) polymorphisms were genotyped via restriction fragment length polymorphism methods in 62 Chinese AIH patients, 77 Chinese PBC patients and 160 healthy controls. RESULTS We found a significant… CONTINUE READING
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