Cytotoxic T-lymphocyte associated antigen 4 gene polymorphisms and autoimmune thyroid disease: a meta-analysis.

  title={Cytotoxic T-lymphocyte associated antigen 4 gene polymorphisms and autoimmune thyroid disease: a meta-analysis.},
  author={Fotini K. Kavvoura and Takashi Akamizu and Takuya Awata and Yoshiyuki Ban and Dimitry Alexandrovich Chistiakov and Irena Frydecka and Abbas Ghaderi and Stephen C. L. Gough and Yuji Hiromatsu and Rafal Ploski and Pei-wen Wang and Tomasz Bednarczuk and Emma I Chistiakova and Marcin Chojm and Joanne M. Heward and Hitomi Hiratani and S. H. Juo and Lidia Karabon and Shigehiro Katayama and Susumu Kurihara and Rue-Tsuan Liu and Ikuyo Miyake and Gholam-Hossein R Omrani and E Dawid Pawlak and Matsuo Taniyama and Teruaki Tozaki and John P. A. Ioannidis},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={92 8},
CONTEXT Cytotoxic T-lymphocyte associated antigen 4 (CTLA-4) polymorphisms have been widely examined for their associations with autoimmune thyroid diseases [Graves' disease (GD) and Hashimoto thyroiditis (HT)], but their relative population effect remains unclear. OBJECTIVE The aim was to generate large-scale evidence on whether the CTLA-4 polymorphisms (A49G and CT60) and haplotypes thereof increase the susceptibility to GD and/or HT. DESIGN, SETTING, AND PARTICIPANTS Meta-analyses of… CONTINUE READING
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